Dextromethorphan misuse is dangerous, and there have been reports of fatal overdoses. Do not give dextromethorphan or any other medications to a pet unless your veterinarian recommends it. If your doctor confirms you’ve had a serious allergic reaction to dextromethorphan, they may have you switch to a different treatment. In general, symptoms of allergic reaction can be mild or serious.
Read our guide on differentiating DMT and near-death experiences to find out. This means that after 20 hours, 97% of the drug will be eliminated from the body. Do not combine it with GHB, alcohol, opioids, tramadol, or benzodiazepines.

Signs And Symptoms Of DXM Abuse
Because of this, it is important to seek emergency care or treatment whenever the signs and symptoms above are observed, as these are more likely to result in coma or death. Dextromethorphan was approved for use by the FDA in the 1950s as a cough suppressant, and it was reported in 2019 that 1 out of every 27 teens abused OTC medications such as Dextromethorphan. Furthermore, a six-year retrospective review study conducted in California in 2008 showed a ten-fold increase in teen DXM addiction rates from 1999 to 2004.
Drug Testing Info
- Read how DMT is helping addicts beat their substance abuse issues.
- Mixing this drug with antidepressants could lead to serotonin syndrome.
- This may result in a mental imbalance that may require hospitalization.
- Without prompt medical care, severe cases of serotonin syndrome can lead to death.
- According to one study, approximately 6,000 emergency department visits each year are attributed to DXM use, and roughly half of those visits are for people between the ages of 12 and 20.
However, recreational use of DXM continued, exploded by the year 2000, and is present today almost everywhere where DXM is available. DXM-containing preparations are usually inexpensive and sold over-the-counter, which makes DXM attractive for minors. DXM may produce euphoria and mind-altering effects when taken in quantities greater than the recommended treatment dose. People who misuse DXM describe different “plateaus” ranging from mild distortions of color and sound to visual hallucinations and “out-of-body” sensations, and loss of motor control. But the concern in the past had been about the alcohol and codeine in cough and cold products.
Dextromethorphan Brand-name Versions
This pushes people to experiment with the amount of the drug and very often leads to DXM abuse and addiction. Dextromethorphan (DXM) is a widely used over-the-counter cough suppressant that has recently overtaken codeine cough syrups (now carefully regulated as Schedule III substances) in popularity. It’s easy to produce, effective and at directed doses, and very safe to use. When used recreationally, DXM should be the only active ingredient in the formulation. This is because many of the cough and cold medicines contain other active ingredients. This includes guaifenesin, acetaminophen, and chlorpheniramine, all of which can be toxic or fatal when taken in large amounts.

Who Should Not Use Dextromethorphan?
The National Institute on Drug Abuse (NIDA) states that DXM misuse is prevalent among adolescents and young adults due to its accessibility and the perception that it is safer than illicit drugs. It has almost no psychoactive effects at medically recommended doses. However, this brand presents additional danger when used at recreational doses due to the presence of chlorpheniramine (antihistamine).
- That being said it is easy to overdo it and 2nd/3rd timers can still get hit pretty hard with doses so DO NOT DOSE 2 MUCH.
- All of them are safe but they will make you trip somewhat differently.
- The Dextromethorphan mechanism of action works as NMDA Receptor Antagonists.
- Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
Is DXM Safe?
The NMDA receptors act as a gate for the transmission of information around the brain. They’re necessary for memory formation and retrieval, conscious thought, and much more. DXM, like other dissociatives, works by blocking the NMDA receptors in the brain.
PCP (Phencyclidine) & Analogs
The information contained on this website is not intended to be a substitute for, or to be relied upon as, medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Regular abuse of DXM at high doses can lead to chemical psychosis.
It can also interact with certain supplements as well as certain foods. Before this we need to highlight the difference between the 3 types of DXM. All of them are safe but they will make you trip somewhat differently. Kindly suggest a cough medicine for my wife, who is 5 months pregnant.

Do not give these products to children younger than 4 years of age. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully. Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if dextromethorphan is right for you. Therefore, such an interaction is likely to increase blood pressure levels and heartbeat rates and induce an uncomfortable feeling, agitation, and restlessness.
What Are The Drugs Which Interact With Dextromethorphan?

In particular, make sure that you discuss if you are taking any monoamine oxidase inhibitor (MAOI) within the past 2 weeks, which is a medicine usually used for depression or Parkinson’s disease. There are no known interactions between dextromethorphan and foods or drinks. Tell your healthcare provider if you have any of the following. Dextromethorphan is available in the following dosage forms that are taken by mouth.
Early recognition and comprehensive treatment are essential for recovery. If you’re concerned about law enforcement getting involved, you don’t need to mention the substances used over the phone. Just be sure to tell them about specific symptoms so they can send the appropriate response.If you’re caring for someone else, get them to lay slightly on their side while you wait.
Recreationally, DXM acts as an NMDA antagonist that produces dissociative, sedating, and stimulating effects, depending on the dose consumed. Anecdotally, some frequent DXM users describe a chronic form of tolerance that may take at least several months to reverse. Because they act on the same receptor systems, DXM is cross-tolerant with other dissociatives, such as PCP and ketamine. DXM is known to produce highly variable reactions from person to person. It’s always best to start with a low dose and gauge one’s individual reaction.
Some teens believe that OTC medicines are safer to abuse because they are legal. When taken in larger amounts, it can distort awareness and alter time perception. Reach out to our team today to start an over-the-counter drug addiction treatment program that can help you make the change you need to succeed. Recovery isn’t always easy, but it is always worth the effort.